The incidence of anaemia and thrombocytopenia is variable. For the aggressive subtypes, combination chemotherapy remains the primary therapy. The prognosis of ATLL is poor, with a median survival of less than one year for the acute and lymphoma forms. Leukaemic picture, organomegaly, high lactate dehydrogenase LDH and often hypercalcaemia.
Most people with the acute and lymphoma types of ATLL have advanced-stage widespread disease when they are diagnosed. The overwhelming majority of patients are from endemic areas of Japan, Caribbean islands, and Sub-Subharan Africa. American Journal of Hematology. Uranyl acetate and lead nitrate stain.